It has been shown that ATD has weak but stable effects on mood ratings in adult patients as well as healthy subjects. Altered mood in children and adolescents with ADHD can confound the differential diagnosis between severe ADHD and mood disorders, e.g. pediatric bipolar disorder. Zepf et al (2009, Human Psychopharmacology) investigated the effects of ATD on mood self-ratings in children with ADHD using a double-blind within-subject crossover-design. On both study days, self-rated mood was assessed at baseline conditions and at three different post-drink time-points. ATD had no clear effect on mood within the whole sample. However, since this was the first study to tackle the issue of mood ratings after ATD in children with ADHD, the study needs to be replicated to allow for more definite conclusions.