Selected literature

             Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN. Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry. 1994 Sep;51(9):687-97. PubMed PMID: 8080345.

             Biskup CS, Sánchez CL, Arrant A, Van Swearingen AE, Kuhn C, Zepf FD. Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. PLoS One. 2012;7(5):e35916. Epub 2012 May 21. PubMed PMID: 22629305; PubMed Central PMCID: PMC3357407.

             Campbell-Meiklejohn D, Wakeley J, Herbert V, Cook J, Scollo P, Ray MK, Selvaraj S, Passingham RE, Cowen P, Rogers RD. Serotonin and dopamine play complementary roles in gambling to recover losses. Neuropsychopharmacology. 2011 Jan;36(2):402-10. Epub 2010 Oct 27. PubMed PMID: 20980990; PubMed Central PMCID: PMC3055672.

             Crockett MJ, Clark L, Lieberman MD, Tabibnia G, Robbins TW. Impulsive choice and altruistic punishment are correlated and increase in tandem with serotonin depletion. Emotion. 2010 Dec;10(6):855-62. PubMed PMID: 21171757; PubMed Central PMCID: PMC3009596.

             Demisch L, Kewitz A, Schmeck K, Sadigorsky S, Barta S, et al. (2002) Methodology of Rapid Tryptophan Depletion (RTD): impact of gender and body weight. Eur Arch Psychiatry Clin Neurosci 252: I/25.

             Dingerkus VL, Gaber TJ, Helmbold K, Bubenzer S, Eisert A, Sánchez CL, Zepf FD. Acute tryptophan depletion in accordance with body weight: influx of amino acids across the blood-brain barrier. J Neural Transm. 2012 Sep;119(9):1037-45. Epub 2012 May 24. PubMed PMID: 22622364; PubMed Central PMCID: PMC3424286.

             Feder A, Skipper J, Blair JR, Buchholz K, Mathew SJ, Schwarz M, Doucette JT, Alonso A, Collins KA, Neumeister A, Charney DS. Tryptophan depletion and emotional processing in healthy volunteers at high risk for depression. Biol Psychiatry. 2011 Apr 15;69(8):804-7. Epub 2011 Mar 5. PubMed PMID: 21377656.

             Hood SD, Hince DA, Davies SJ, Argyropoulos S, Robinson H, Potokar J, Nutt DJ. Effects of acute tryptophan depletion in serotonin reuptake inhibitor-remitted patients with generalized anxiety disorder. Psychopharmacology (Berl). 2010 Feb;208(2):223-32. Epub 2009 Nov 21. PubMed PMID: 19936713.

             Kaye WH, Barbarich NC, Putnam K, Gendall KA, Fernstrom J, Fernstrom M, McConaha CW, Kishore A. Anxiolytic effects of acute tryptophan depletion in anorexia nervosa. Int J Eat Disord. 2003 Apr;33(3):257-67; discussion 268-70. PubMed PMID: 12655621.

             Mace JL, Porter RJ, Dalrymple-Alford JC, Wesnes KA, Anderson TJ. The effects of acute tryptophan depletion on neuropsychological function, mood and movement in the healthy elderly. J Psychopharmacol. 2011 Oct;25(10):1337-43. Epub 2011 Jan 24. PubMed PMID: 21262857.

             Mendelsohn D, Riedel WJ, Sambeth A. Effects of acute tryptophan depletion on memory, attention and executive functions: a systematic review. Neurosci Biobehav Rev. 2009 Jun;33(6):926-52. Epub 2009 Mar 18. Review. PubMed PMID: 19428501.

             Moore P, Landolt HP, Seifritz E, Clark C, Bhatti T, Kelsoe J, Rapaport M, Gillin JC. Clinical and physiological consequences of rapid tryptophan depletion. Neuropsychopharmacology. 2000 Dec;23(6):601-22. Review. PubMed PMID: 11063917.

             Robinson OJ, Cools R, Sahakian BJ. Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience. Psychopharmacology (Berl). 2012 Jan;219(2):599-605. Epub 2011 Jul 19. PubMed PMID: 21769566; PubMed Central PMCID: PMC3249152.

             Roiser JP, Levy J, Fromm SJ, Goldman D, Hodgkinson CA, Hasler G, Sahakian BJ, Drevets WC. Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers. J Psychopharmacol. 2012 Apr 10. [Epub ahead of print] PubMed PMID: 22495688.

             Satel SL, Krystal JH, Delgado PL, Kosten TR, Charney DS. Tryptophan depletion and attenuation of cue-induced craving for cocaine. Am J Psychiatry. 1995 May;152(5):778-83. PubMed PMID: 7726319.

             Stadler C, Zepf FD, Demisch L, Schmitt M, Landgraf M, Poustka F. Influence of rapid tryptophan depletion on laboratory-provoked aggression in children with ADHD. Neuropsychobiology. 2007;56(2-3):104-10. Epub 2008 Jan 10. PubMed PMID: 18182830.

             Stadler C, Zepf FD, Demisch L, Schmitt M, Landgraf M, Poustka F. Influence of rapid tryptophan depletion on laboratory-provoked aggression in children with ADHD. Neuropsychobiology. 2007;56(2-3):104-10. Epub 2008 Jan 10. PubMed PMID: 18182830

             Toker L, Amar S, Bersudsky Y, Benjamin J, Klein E. The biology of tryptophan depletion and mood disorders. Isr J Psychiatry Relat Sci. 2010;47(1):46-55. Review. PubMed PMID: 20686199.

             van Veen JF, van Vliet IM, de Rijk RH, van Pelt J, Mertens B, Fekkes D, Zitman FG. Tryptophan depletion affects the autonomic stress response in generalized social anxiety disorder. Psychoneuroendocrinology. 2009 Nov;34(10):1590-4. Epub 2009 Jun 11. PubMed PMID: 19523772.

             Weltzin TE, Fernstrom MH, Fernstrom JD, Neuberger SK, Kaye WH. Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa. Am J Psychiatry. 1995 Nov;152(11):1668-71. PubMed PMID: 7485633.

             Wurtman RJ, Hefti F, Melamed E. Precursor control of neurotransmitter synthesis. Pharmacol Rev. 1980 Dec;32(4):315-35. PubMed PMID: 6115400.

             Zepf FD, Gaber TJ, Baurmann D, Bubenzer S, Konrad K, Herpertz-Dahlmann B, Stadler C, Poustka F, Wöckel L. Serotonergic neurotransmission and lapses of attention in children and adolescents with attention deficit hyperactivity disorder: availability of tryptophan influences attentional performance. Int J Neuropsychopharmacol. 2010 Aug;13(7):933-41. Epub 2010 Mar 3. PubMed PMID 20196917.

             Zepf FD, Holtmann M, Stadler C, Demisch L, Schmitt M, Wöckel L, Poustka F. Diminished serotonergic functioning in hostile children with ADHD: tryptophan depletion increases behavioural inhibition. Pharmacopsychiatry. 2008 Mar;41(2):60-5. PubMed PMID: 18311686.

             Zepf FD, Holtmann M, Stadler C, Wöckel L, Poustka F. Reduced serotonergic functioning changes heart rate in ADHD. J Neural Transm. 2009 Jan;116(1):105-8. Epub 2008 Nov 19. PubMed PMID: 19018449.

             Zepf FD, Stadler C, Demisch L, Schmitt M, Landgraf M, Poustka F. Serotonergic functioning and trait-impulsivity in attention-deficit/hyperactivity-disordered boys (ADHD): influence of rapid tryptophan depletion. Hum Psychopharmacol. 2008 Jan;23(1):43-51. PubMed PMID: 17926336.

             Zepf FD, Wöckel L, Poustka F, Holtmann M. Dietary tryptophan depletion according to body weight - a new treatment option in acute mania? Med Hypotheses. 2009 Jan; 72(1):47-8. Epub 2008 Oct 11. PubMed PMID: 18849122.

             Zepf FD, Wöckel L, Poustka F, Holtmann M. Diminished 5-HT functioning in CBCL pediatric bipolar disorder-profiled ADHD patients versus normal ADHD:susceptibility to rapid tryptophan depletion influences reaction time performance. Hum Psychopharmacol. 2008 Jun;23(4):291-9. PubMed PMID: 18421802.

             Zepf Principles of Rapid Tryptophan Depletion and its Use in Research of Neuropsychiatric Disorders (F.D. Zepf, Amino Acids in Human Nutrition and Health, CAB International 2012).

             Zimmermann M, Grabemann M, Mette C, Abdel-Hamid M, Uekermann J, Kraemer M, Wiltfang J, Kis B, Zepf FD. The effects of acute tryptophan depletion on reactive aggression in adults with attention-deficit/hyperactivity disorder (ADHD) and healthy controls. PLoS One. 2012;7(3):e32023. Epub 2012 Mar 14. Erratum in: PLoS One. 2012;7(3). doi: 10.1371/annotation/e575c960-6acb-47fc-af2b-212f13164aaf. Ueckermann, Jennifer [corrected to Uekermann, Jennifer]. PubMed PMID: 22431971; PubMed Central PMCID: PMC3303767.